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Leptin resistance looks to be due to a reduction in its transport across the blood-brain barrier, in addition to its lowered ability to initiate cellular activation within the brain

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European Journal of Applied Physiology, 116, 415425

10.1055/s-0039-1681032 64 MohamedA

Enzymatic or microbial stability: Biopolymer-based carriers such as resistant starch (RS), inulin-type fructans and pectin-based matrices can resist immediate digestion by human amylases and proteases, which is useful for protecting ingredients until they reach the colon