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(28152637) IV L-arginine might be a reasonable consideration in the following situations: i) Moderate to severe hyperammonemia, without immediate access to hemodialysis ii) Persistent hyperammonemia, despite hemodialysis iii) Hyperammonemia which poses an immediate threat to life (e.g., moderate to severe hyperammonemia with evidence of cerebral edema) A reasonable dose may be: (22642880) Loading bolus of 250 mg/kg (1.2 mM/kg) over 2 hours

plan extra to cover the full cycle

However, injecting significantly early could accelerate drug accumulation

Pigs are often considered the most translational model for human liver metabolism due to similarities in CYP450 expression, bile acid composition, and liver-to-body weight ratio (25)

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