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Notably, the present narrative review is an extension of a previous review article that covered polyphenols and/or phytoestrogens that included daidzein, equol, genistein, and resveratrol as supplemental therapies for skin aging, which was published in Dermatology and Therapy earlier this year by Lephart (2025) [9]

The levels of aglycones produced in our body are known to be affected by multiple factors, and the occurrence of acute hemolytic anemia in G6PD-deficient patients is reported to be dose-dependent ( The severity of favism was compared between three distinct G6PD-deficient variants in the Palestinian Gaza community (38)

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The reality is that while animal studies seem promising, we have very little data on BPC-157's long-term effects in humans