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The results revealed that melatonin could directly react with and remove hydroxyl radicals

Findings: RCTSTEP-HFpEF DM trial - Semaglutide vs Placebo in Obese Diabetics with HFpEF, NEJM (2024) [PubMed abstract] Design: Randomized, placebo-controlled trial (N=616 | length = 52 weeks) in obese type 2 diabetics (BMI 30) with HFpEF Treatment: Semaglutide titrated to 2.4 mg once weekly vs Placebo Primary outcome: Change from baseline in the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS

Data Availability Statement The data of the present study are available upon request to the corresponding author

We conducted the chart reviews using the Computerized Patient Record System of VA Long Beach Healthcare System to assess if immune-related adverse events occurred after receiving 1 or more doses of a checkpoint inhibitor