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As shown in Figure 2, most control fresh oocytes were normal in morphology

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Orally delivered NAC undergoes extensive first-pass metabolism resulting in about 90% loss by enzymatic deacetylation to form cysteine in the small intestine [9]

Mathematically, reaching true steady state would take an infinite amount of time, but clinically, it is considered achieved after approximately 5 half-lives of continuous infusion, at which point the plasma drug concentration will be between 95% and 99% of the true steady-state level

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Interestingly, glutathione (GSH) content and GSH-peroxidase and GSH reductase enzymes as well as superoxide dismutase (SOD) activities were profoundly altered in diabetic rat tissues