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Administering UA to adult rats either 24 h before middle cerebral artery occlusion (62.5 mg/kg, intraperitoneally) or 1 h after reperfusion (16 mg/kg, intravenously) can protect cultured hippocampal neurons from cell death induced by brain ischemia-related damage, including exposure to excitatory amino acids, glutamate, and the metabolic poison cyanide [139]

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Kitano D, Chiku M, Li Y, Okumura Y, Fukamachi D, Takayama T, Hiro T, Saito S, Hirayama A