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What Mechanistic Evidence Can and Cannot Prove Rodent mechanistic findings support why the warning exists Human mechanistic data does not confirm a comparable risk pathway Therefore, the burden shifts to high-quality human data Bottom Line: If GLP-1 drugs caused MTC in humans like in rodents, we'd expect clearer biologic signals in human C-cells and biomarkers

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Its almost never-ending. (The phenomenon of GLP-1s seemingly changing peoples skin is something Allure first reported on last summer.) Still, doctors generally agree that theres little hard evidenceas in, biopsy studies examining skin structure and function before and after GLP-1 useproving that these medications truly alter the tissues at a molecular level

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