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67,179 This second phase of acute focal TBI is complete about a month after the insult, when the mature lesion, composed of the central fibrotic scar (fully devoid of neural elements) and the surrounding astroglial limitans border have formed

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Similarly, the in vivo results indicated an increased effectiveness of cisplatin in both parental and cisplatin-resistant tumors, though a significantly higher cure rate was assessed in cisplatin-sensitive compared to cisplatin-resistant tumors: 85% and 6%, respectively, at the same 8-mg/kg dose (65)

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An increase in the level of free oxygen radicals may cause mutagenicity, cytotoxicity, and changes in gene expression, leading to the development of malignant tumors, and this mutagenicity may contribute to the transformation of benign development into malignant [41]