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Important safety considerations include: Increased hypoglycaemia risk when used with insulin or sulfonylureas (dose adjustments of these medications may be needed) Potential worsening of diabetic retinopathy with rapid improvement in blood glucose control, particularly with semaglutide Need for monitoring in patients with pre-existing retinopathy The MHRA continues to monitor the safety profile of these agents
Anti-oxidants are the electron donors.
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Alcohol: Avoid alcohol on DSIP dosing nights
It is formulated for monthly injection and studied both alone and in combo with the GLP-1 analog
Early DPP4is that also blocked DPP8 and DPP9 exhibited severe toxicity in preclinical animal models [64]
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