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The diarrhea and dehydration caused by the drug can lead to increased blood viscosity, increasing the risk for the formation of blood clots

Valentijn AJ, Saretzki G, Tempest N, Critchley HO, Hapangama DK

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Why receptor subtype work matters for interpretation A common question is which receptor subtype is doing the work. A 2025 mechanistic study investigated AMY receptor subtype dependence and reported that cagrilintides body weight lowering effects depended on AMY1R and AMY3R in their models, which provides a more concrete receptor anchored explanation than general appetite language