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In Chronic Obstructive Pulmonary Disease (COPD), hypermethylation of the NRF2 promoter leads to decreased NRF2 expression in the lungs of patients, resulting in the inhibition of the NRF2-GPX4 axis and subsequent induction of ferroptosis

However, as unmeasured confounding was possible, and the as-treated analyses were prone to time-varying confounding due to informative censoring, the estimates should be cautiously interpreted

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Another study found that liraglutide also reduced the activation of microglial cells in the brain's cortex and thalamus in diabetic rats by lowering the expression of NLRP3 protein, a marker of inflammation in brain microglia [104]

MTHF is able to methylate homocysteine to methionine

Endocr Rev (2018) 392:13353