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Intriguingly, despite robust inflammatory activation, they reported no changes in the expression of canonical tight junction proteins (e.g., Cldn5), adherens junction molecules (e.g., Cdh1), or components of the basal lamina across both early and late phases of the disease model

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Positioned strategically throughout the central nervous system (CNS), in the meninges, choroid plexus, perivascular spaces, and even adjacent to neurons, mast cells maintain close contact with neurons, glia, and endothelial cells