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injection with 200 nmol kg 1 MK-801, 600 nmol kg 1 MK-801 or vehicle, and for measurement of rectal temperature on day 14 of mice receiving 14 days of once-daily s.c

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However, you may notice changes in appetite and blood sugar level after 4-5 weeks as soon as the medication reaches a steady-state concentration

The other explanation might be that mitochondrial biogenesis per se is not always assayed