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In animal and human cell cultures, extracts from G

Activation of GHRH-R adenylate cyclase increased intracellular cAMP activation of PKA phosphorylation of the transcription factor CREB increased transcription of the GH gene increased intracellular GH stores in vesicles

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Administered once weekly via subcutaneous injection, starting at 2.5 mg and titrated every 4 weeks to a maintenance dose of 515 mg