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Murphey MD, Smith WS, Smith SE, Kransdorf MJ, Temple HT

[Google Scholar] 36.Kwon DR, Park GY

Furthermore, in line with findings from 92 that reported reduced proteasome activity in SH-SY5Y dopaminergic cells following USP14 knockout, and 52 , that reported impaired proteasome function in OLN-t40 oligodendroglial cells upon global DUB inhibition by PR619, we observed diminished CT-L proteasome activity following chronic (24 h) DUB inhibition in iNeurons

WO 00/53148 discloses and claims a "method for the treatment of erectile dysfunction which comprises administering to a human subject in need of such treatment an effective amount of an agonist of the melanocortin receptor in combination with an effective amount of a cyclic-GMP- specific phosphodiesterase inhibitor or an alpha-andrenergic receptor antagonist. MT-II is a disclosed melanocortin receptor agonist and sildenafil is a disclosed PDE-5 inhibitor

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Hence, comprehensive analysis of the human metabolome is emerging as a promising tool for understanding the molecular basis of a variety of pathologies [22, 23]