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The two core mechanism papers were retracted in April 2025 (Kawas 2012, PMID 22129598, retraction notice PMID 40312092

Once formed, glutathione cycles between its reduced (GSH) and oxidized (GSSG) states to maintain cellular balance

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10.1172/JCI115090 25

Consistency matters because the 7-day half-life means plasma levels stay most stable with regular weekly intervals