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Objectives To ensure timely and accurate administration of injectable medications

Patients may feel a brief heating sensation immediately followed by a cooling sensation as the adapter touches the skin

Raun et al., 1998 European Journal of Endocrinology Researchers tested different peptides to see how strongly (and selectively) they stimulated GH release

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GLP-1 receptor agonists slow gastric emptying and may alter energy use - which could, in theory, contribute to a colder baseline feeling