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The molecular basis is multifaceted

10.1016/j.freeradbiomed.2018.09.014 71 ShahR.ShchepinovM

Nrf2 is a major regulator of the cellular oxidative stress response and maintenance of redox homeostasis ( 2.3 Cisplatin induces mitochondrial dysfunction When cisplatin enters the mitochondria, it acts directly on the inner mitochondrial membrane, leading to the impairment of the function of the electron transport chain, the reduction of ATP production and the induction of ROS generation ( Dysfunctional mitochondria release into the cytoplasm, it binds to with Apaf-1, triggering caspase-9, caspase-3 related cascade reactions that lead to apoptosis (Figure 2)

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Stored retinoids in populations of the estuarine fish Fundulus heteroclitus indigenous to PCB-contaminated and reference sites