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Symptoms of excessive IGF-1 may include water retention, joint pain, carpal tunnel symptoms, or increased sweating

Route of Administration: Oral gavage, subcutaneous injection, intraperitoneal injection each route has distinct implications for absorption, bioavailability, and systemic exposure

More recently, a phase IIb study in AD ( n = 206) reported 12 months of treatment with liraglutide slowed cognitive decline (ADAS-EXEC) by approximately 18% and attenuated cortical atrophy by approximately 50% (140)

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