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The widely repeated claim that it is ~ten-million-fold more potent than BDNF is a relative in-vitro spine-counting ratio, not a human effect, and key mechanism papers from the originating lab were retracted in 2025

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They complement each other, so most people alternate them rather than choosing one

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Among them, NLRP3 is a core member of the caspase-1-dependent inflammasome (Coll et al., 2022)

The combination of niacinamide and salicylic acid (also known as BHA, or beta hydroxy acid) is especially effective for addressing pigmentation disorders like melasma, as well as for oily or combination skin