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About Metformin

The high frequency of the NAT2 and also NAT1 acetylation polymorphism in human population together with ubiquitous exposure to aromatic and heterocyclic amines suggest that and acetylator genotypes are important modifiers of human cancer susceptibility

The mechanism goes like this

Critics have dubbed it the Steroid Olympics

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Liang CM, Lee N, Cattell D, Liang SM