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That application is based on results from large, late-stage studies designed to show how well the treatment works and how safe it is

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In addition, SS-31-treated cells exhibited increased eNOS expression, supporting a direct role of mitochondrial protection in improving nitric oxide bioavailability [49]

These islet infiltrating macrophages are predominantly characterized as a pro-inflammatory phenotype and release potent inflammatory mediators (such as IL-1 and CCL2) that promote -cell apoptosis (64)