When semaglutide binds to GLP-1 receptors in the pancreas, it helps increase insulin secretion based on glucose levels
Additionally, loss of muscle mass (sarcopenia), which occurs with ageing, decreases basal metabolic rate since muscle tissue burns more calories at rest than adipose tissue
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Therefore, TRZ has a good therapeutic window with minimal toxicity (Min and Bain 2021)
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Data analysed by two-way repeated measures ANOVA to assess main effects of treatment ( b , c , f , g , i and j )