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2020 Dec;13(6):65

Similarly, a post-hoc analysis of SURPASS-1, enrolling 478 patients with T2D, found that all doses of tirzepatide as monotherapy increased insulin sensitivity compared to placebo, as suggested by the decreases in HOMA2-IR by 923% (vs +14.7% with placebo) and fasting insulin levels by 212% (vs +15%) and the increase in adiponectin by 1623% (vs 0.2%) and IGFBP-2 by 3870% (vs +4.1%) at 40 weeks [76]

THE FIT PROGRAM INCLUDED ADULT PATIENTS WITH CHRONIC ITP WHO HAD RECEIVED 1 PRIOR THERAPY FIT program patients were representative of the general adult chronic ITP population, including exposure to prior therapies TAVALISSE dosing 3 Starting dose of TAVALISSE: One 100 mg tablet BID Based on platelet count and tolerability, the dose could be increased to one 150 mg tablet BID at or after week 4 Patients who had a platelet count 50 x 10 9 /L at the time of rollover to the FIT-3 open-label extension study maintained their existing dose of TAVALISSE References: 1

GHK-Cu may stimulate new blood vessel formation, a process called angiogenesis

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