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The thioesterase (TE) domain is able to release the target peptide by either hydrolysis or cyclization 12,15,16 and is supposed to condense tetradepsipeptides, first to produce an octadepsipeptidyl- O -TE and then a decadepsipeptidyl- O -TE, followed by macrolactonization to form the cyclic twelve residue product cereulide 8,9

Balasubramanian, A

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An excessive production of oxygen radicals in the cell may also cause morphological disturbances