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Furthermore, genes cntA and cntB of the operon encode for a two-component carnitine monooxygenase which facilitates the initial C-N bond cleavage of L-carnitine which results in the formation of trimethylamine (TMA) and malic semialdehyde (MSA) (Zhu et al., 2014)

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Immediate-release (IR) metformin reaches peak plasma concentrations approximately 2 to 3 hours after oral administration, while extended-release (ER) formulations peak around 7 hours after intake