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The level of TMAO was significantly positively correlated with the incidence of calcification in the intimal lesion ( via promoting fatty acid metabolism and mitochondrial dysfunction (61)

FDA notice on Zepbound/ Mounjaro shortage: On October 2, 2024, the U.S

Collectively, these data indicate that PNPLA3 I148M homozygotes exhibit a distinct metabolic phenotype, marked by impaired lipid droplet turnover, altered mitochondrial function, and modified hepatic lipid flux, that may blunt expected therapeutic responses to some steatosis-targeting strategies

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DeCoste SD, Imber MJ, Baden HP

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