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(26) GLP-1 agonists also demonstrated consistent reductions in lower limb amputation risk across subgroups, including those with peripheral arterial disease (PAD) and patients on antihypertensive therapy

Common Side Effects & Adverse Reactions

Aronne notes that diabetes is also a leading cause of amputation

HbA1c re-test

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Although comparison studies with GLP-1 RA's have been conducted in the past, new doses have since been approved, making it difficult to compare tirzepatide to GLP-1 RA's based on previous studies