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For signicant deciencies, injections might be administered more frequently at the start (e.g., weekly), and once levels stabilize, the frequency can be reduced (e.g., monthly)

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For a 75 to 90kg adult, that translates roughly to 190 to 900mcg daily, which brackets the 200 to 500mcg range being used in practice

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Nature, 243(5407), 352354

Political pressure from patients who rely on affordable compounded alternatives creates a counterbalance to pharmaceutical industry lobbying