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Abbreviations CLP: Cecal ligation and puncture CCK: Cell viability analysis by cell counting kit-8 ELISA: Enzyme-linked immunosorbent assay ERR: Estrogen-related receptor alpha H&E: Hematoxylin and eosin FTH1: Ferritin heavy chain 1 GPX4: Glutathione peroxidase 4 ICU: Intensive care unit LPS: Lipopolysaccharides NRF2: Nuclear factor erythroid 2-related factor 2 NOX1: Nicotinamide adenine dinucleotide phosphate-oxidase 1 SABD: Sepsis-associated brain dysfunction ROS: Reactive oxygen species WB: Western blotting iNOS: Inducible nitric oxide synthase Arg-1: Arginase-1 References Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M,