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Prior to starting the study, the investigators used PASS software (version 11) to calculate minimum sample size 11

Then, let it dry completely before proceeding to the next step

In this global registration trial, where 84.0% of participants had a baseline BMI of 35 kg/m, each dose of retatrutide (9 mg and 12 mg) met all primary and key secondary endpoints, delivering significant weight loss and improvements in pain and physical function at 68 weeks using both the efficacy and treatment-regimen estimands

Dont Ignore Sleep and Stress Two silent plateau-causers: lack of sleep and chronic stress

Weeks 8 to 12: Reaching the Therapeutic Threshold Significant progress generally occurs once the medication reaches a steady state in your system

Use gel packs or cold packs, but ensure they are not frozen solid when placed next to the vial, as this could freeze the medication