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They are not just reducing headaches through some vague anti-inflammatory effect

Lopresti et al., 2021a

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline Solubility: 2.5 mg/mL (4.95 mM)

Neuroprotective properties of citicoline: facts, doubts and unresolved issues

The main targets in these models are thyroid follicular cells, immune cells (particularly T lymphocytes), and the autoantibodies that bind to thyroid antigens