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Model appropriateness and population pharmacokinetic modeling

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The kidney expresses GGT at the highest levels, while notable expression is also found in bile canaliculi of hepatocytes, ducts within the pancreas, the apical surface of the intestinal epithelium and the luminal surface epithelium of many reproductive organs (25)

This pattern mirrors how regulators like NAD are tracked across aging, mapping core metabolic players in detail long before they become medicines

This intriguing modification extends beyond histones to non-histone proteins, signaling molecules, enzymes, and substrates