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In addition, the protective effects of both a recombinant adiponectin injection in ob/ob mice and metformin administration against NAFLD have been attributed, at least in part, to the inhibition of hepatic TNF expression 24,25

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Methylglyoxal undergoes spontaneous thiolation with GSH, followed by the Glo-1 catalyzed conversion of methylglyoxal thioacetal to (S)-lactoylglutathione [232,233]

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