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IV glutathione bypasses absorption issues entirely and raises plasma levels dramatically, but its expensive ($100200 per infusion), requires clinical visits, and isnt necessary for most patients using the stack

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Pharmacokinetics Absorption In patients with type 1 diabetes, after 8 days of once daily subcutaneous dosing with 0.4 units/kg of TRESIBA, maximum insulin degludec concentrations of 4472 pmol/L were attained at a median of 9 hours (tmax)

If you are taking medications, particularly anticoagulants, or have concerns about blood clotting, you should consult with a healthcare professional before starting this combination