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Choice of control (Control) A pure 2-arm, placebo-controlled, RCT between a single drug and placebo may not be acceptable for prospective participants to be randomised into, given documented multi-systemic benefits of GLP-1 administration

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Interestingly, increase in fatty acid utilization mediated by GPER may lead to dual effects, usually depending on the specific tumor type and microenvironment: fatty acid metabolism provides additional energy and biosynthetic precursors to tumor cells, increasing their metabolic capacity and promoting rapid tumor growth [240]

Previous research has shown that people have difficulty paying for a medication when the cost rises above $100 per month, said Stacie Dusetzina, a Vanderbilt University Medical Center professor and prescription drug pricing expert

337 Cariou, B

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