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They are susceptible to degradation pathways that small molecules simply do not face, including deamidation, oxidation, aggregation, and hydrolysis
10.1093/ajcn/nqab152 Am J Clin Nutr
10 While these effects have been associated with indirect mechanisms such as glucose control and weight loss, scientists have also observed that some of the anti-inflammatory effects begin before a significant reduction in adiposity is achieved
The case for considering it is straightforward: the underlying drug class (GLP-1 receptor agonists) has the strongest weight management evidence base in clinical pharmacology, supported by multiple large-scale randomized controlled trials showing 15-22% weight reduction in study populations over 68-72 weeks
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