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In addition, in non-obese diabetic mice, DPP-IV inhibitors significantly increase Treg expansion and TGF- level

3 If initial therapy with metformin and lifestyle efforts are not adequate to achieve individualized glycemic targets, the guidelines recommend that patients should progress to dual therapy by adding either another oral agent, basal insulin, or an injectable GLP-1 receptor agonist

Despite the name, this issue is not unique to people on GLP-1 agonist medications

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For dual receptor agonists, trials provide measurable data on blood sugar control, weight loss, metabolic improvements, and potential side effects, guiding dosage and patient selection

What About Safety And What Should You Ask