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Mechanisms vary, but lithium reportedly induces sporadic thyroiditis by direct toxic effects

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The incidence of hypoglycemia accompanied by a self-monitored or plasma glucose value less than 54 mg/dL regardless of symptoms in patients with type 2 diabetes receiving Insulin Glargine, U-300 ranged from 9% to 44.6% at 26 weeks and the highest risk was again seen in patients receiving Insulin Glargine, U-300 as part of a multiple daily injection regimen