When you calculate AHK-Cu dosage to be a very small volume, this becomes critically important
Over a 48-hour period, approximately 136 g/cm of copper permeated skin, with an additional 82 g/cm retained in tissue as a depot, suggesting sustained biological activity following application
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Sci Rep (2021) 11(1):14987
This is seen from both the transcriptomics studies and the ROS determination