This is a great question, and the answer really comes down to your individual health picture
According to clinical trial results, users of tirzepatide had nearly a threefold higher risk of gastrointestinal issues, while users of semaglutide had less than a twofold higher risk compared to those receiving a placebo
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In animal experiments, the GLP-1RA liraglutide was found to stimulate the secretion of ANP by increasing the levels of Epac2, which is a downstream target of GLP-1R signaling in cardiomyocytes (132), However, this finding seemed to contradict the results of clinical studies in which no increase was observed in the levels of ANP in healthy people and patients with T2MD
How semaglutide works to control hunger Semaglutide (the active ingredient in Ozempic and Wegovy) mimics a hormone called GLP-1 that your body naturally produces after eating