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In a detailed follow-up analysis of SELECT, researchers found: People got similar cardiovascular protection whether they: lost 5% of body weight, or lost very little weight (or even none) Thats a major finding because it suggests semaglutide may protect the heart through multiple pathways, such as: lowering inflammation improving blood vessel function reducing blood pressure improving cholesterol and lipid markers In SELECT, semaglutide also improved several risk indicators, including lower blood pressure and a major drop in C-reactive protein (CRP) a marker linked with inflammation and heart risk
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As an evolutionary strategy to counteract truncation-induced toxicity resulting from impaired proteostasis, the cellular system employs compensatory responses such as phosphorylation near truncation sites
Mol Ther 2013;21:1830
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