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Findings Originally developed for T2DM, GLP-1RAs have demonstrated efficacy in reducing weight and improving glycemic control and CV outcomes

Metallothionein, the only known protein implicated in cellular zinc distribution, binds 7 zinc atoms via thiolated ligands

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Higher doses of oral semaglutide (up to 50 mg/day) are under development for the treatment of both T2DM (104) and obesity (105), with effectiveness on par with 2.4 mg/week subcutaneous semaglutide approved for weight management

A landmark study published in Diabetes Care found that participants consuming as little as 1 gram daily experienced significant reductions in serum glucose, triglycerides, and LDL cholesterol