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Critically, these events were most prevalent during initiation/escalation of therapy and declined substantially over time

Such direct inhibitory action appears surprising for a peptide thought to be primarily involved in sleep promotion

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These results indicate that treatment with GABA, DSIP-CBBBP and more effectively reduced wakefulness time, with DSIP-CBBBP showing the most substantial reduction, suggesting its potential as a therapeutic agent for mitigating insomnia