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(The same conditions afflicted only about one-sixth of participants who received a placebo.) Burping, a.k.a

Efficacy loss may indicate an underlying neuroendocrine issue rather than peptide failure

Similar to the transcriptomic changes observed in the hypothalamus, we found that the conjugate prompted transcriptional patterns enriched for functional terms associated with synaptic transmission, including postsynaptic specialization and neuron-to-neuron synapse in the brainstem (Extended Data Fig

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