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Clinical studies show participants losing an average of 16% to 22+% of their body weight

Population studies indicate increased systemic oxidative stress biomarkers in hypertensive patients, correlating oxidative stress with a higher risk of hypertension even in normotensive individuals [247]

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doi:10.1152/physrev.00034.2006 108

Unfortunately, for some people, this can result in super negative side effects like nausea, vomiting, and diarrhea - one study reported that 50% of patients taking GLP-1 agonists experienced nausea while taking them