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Ligand binding to TLRs typically recruits the adaptor protein myeloid differentiation primary response 88 (MyD88), thereby triggering major pro-inflammatory signaling cascades, including the MAPK and nuclear factor kappa B (NF-B) pathways (165, 259)

2.2 Cecal ligation puncture in mice The mice were randomly assigned to either the Sham group or the CLP group

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You may notice changes in bowel habits, mild nausea (particularly after meals), or a sensation of fullness that persists longer than usual