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Semaglutide's most common adverse effectsnausea, vomiting, diarrhea, and abdominal painare dose-dependent and typically occur during dose escalation

Persistent pain or discomfort merits a pelvic exam to exclude dermatologic conditions or infection

Similar content being viewed by others 1 Introduction Significant challenges in obtaining sufficient systemic exposure of orally administered peptide- and protein-based drugs are due to the acidic environment and presence of proteolytic enzymes in the stomach, and the limited permeability of peptides and proteins through the gastrointestinal epithelium [1, 2]

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Daytime and nighttime outcomes are reported in Supplementary Table 4