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Although the hypotensive effect of GLP-1 RAs seems to be manifested by BW losing, other mechanisms not related to BW might be implied by the mediation meta-analysis, which suggests an existence of BW-independent hypotensive effect of GLP-1 RA, along with the clinical evidence of weak or no correlations, and difference in time course between BP lowering and BW reducing effects

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It highlights the distinction between adaptive circadian remodeling during normal aging and pathological circadian disruption linked to disease, providing a conceptual framework for understanding age-dependent alterations in sleepwake regulation

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10.1056/NEJMOA2108269 18 GiuglianoD.ScappaticcioL.LongoM.BellastellaG.EspositoK