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Other factors which involve a lack of information and potentially contribute to heterogeneity include concomitant illnesses and medications, both of which may affect antioxidant status

Future studies using melatonin-competent mice, genetic validation of receptor independence, and time-of-day dosing paradigms will be critical to determine whether the melatoninglutathione axis can be exploited therapeutically to treat asthma

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Research indicates that RPE cells from individuals with AMD exhibit elevated ROS levels and an increased susceptibility to oxidative stress compared to RPE cells from non-AMD donors [421]